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Linzolid | Linezolid 600
Linezolid
- Hospital-acquired pneumonia (nosocomial)
- Community-acquired pneumonia
- Complicated skin and soft tissue infections (including diabetic foot ulcers without bone involvement)
- Uncomplicated skin and soft tissue infections
- Infections caused by vancomycin-resistant Enterococcus faecium
Note: Linzolid is not effective against Gram-negative infections. Safety for use beyond 28 days has not been studied in clinical trials.
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✅ Description:
Linezolid is a synthetic oxazolidinone antibiotic that inhibits bacterial protein synthesis by binding to the 23S portion of the 50S ribosomal subunit, preventing formation of the 70S initiation complex.
Bacteriostatic against staphylococci and enterococci
Bactericidal against most streptococci
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
Diarrhea, nausea, headache, Oral/vaginal candidiasis, high blood pressure, dyspepsia, itching, abdominal pain, tongue discoloration
✔️ Dosage & Administration
| Infection Type | Pediatric Patients (Birth–11 years) | Adults/Adolescents (≥12 years) | Duration |
|---|---|---|---|
| Nosocomial pneumonia | 10 mg/kg IV/PO every 8h | 600 mg IV/PO every 12h | 10–14 days |
| Community-acquired pneumonia | 10 mg/kg IV/PO every 8h | 600 mg IV/PO every 12h | 10–14 days |
| Complicated skin infections | 10 mg/kg IV/PO every 8h | 600 mg IV/PO every 12h | 14–28 days |
| Uncomplicated skin infections | <5 yrs: 10 mg/kg PO every 8h 5–11 yrs: 10 mg/kg PO every 12h | Adults: 400 mg PO every 12h Adolescents: 600 mg PO every 12h | 10–14 days |
Neonates <7 days old (esp. <34 weeks gestation): Start with 10 mg/kg every 12h, may increase to every 8h based on response.
No dose adjustment needed when switching from IV to oral route.
✔️ Drug Interactions
Serotonin Syndrome Risk: Avoid with SSRIs, SNRIs, tricyclics, buspirone, meperidine, triptans
Blood Pressure Effects: Caution with vasopressors, dopaminergic agents
Tyramine-containing foods: Avoid aged cheese, fermented products, soy sauce, etc.
✔️ Contraindications
- Known hypersensitivity to Linezolid
- Concurrent or recent use (within 2 weeks) of MAO inhibitors
- Patients with uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome
- Use with serotonergic or adrenergic agents (e.g., SSRIs, tricyclics, triptans, pseudoephedrine)
✔️ Use in Pregnancy & Lactation
- Pregnancy: Limited data; use only if benefits outweigh risks
- Lactation: Present in breast milk; monitor infant for vomiting, diarrhea
✔️ Precautions & Warnings
- Monitor blood counts weekly, especially if used >2 weeks or in patients with myelosuppression
- Visual disturbances: Prompt ophthalmologic exam if visual symptoms arise
- Not recommended for catheter-related bloodstream infections
- Risk of C. difficile-associated diarrhea (CDAD) up to 2 months post-treatment
- Monitor for lactic acidosis, unexplained vomiting, or metabolic issues
- Use with caution in diabetics due to risk of hypoglycemia
✔️ Storage:
Store between 15°C–30°C, protect from light and moisture
Keep out of reach of children
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
